Developmental Gene Expression of Antimicrobial Peptide PR-39 and Effect of Zinc Oxide on Gene Regulation of PR-39 in Piglets

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Antimicrobial and Immunomodulatory Activities of PR-39 Derived Peptides

The porcine cathelicidin PR-39 is a host defence peptide that plays a pivotal role in the innate immune defence of the pig against infections. Besides direct antimicrobial activity, it is involved in immunomodulation, wound healing and several other biological processes. In this study, the antimicrobial- and immunomodulatory activity of PR-39, and N- and C-terminal derivatives of PR-39 were tes...

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Chemoattractant properties of PR-39, a neutrophil antibacterial peptide.

The proline-arginine (PR) -rich antibacterial peptide, PR-39, kills bacteria by a non-pore-forming mechanism. Because this neutrophil peptide possesses several distinct functional properties and because other antimicrobial peptides are chemoattractants, we sought to determine whether PR-39 was a chemoattractant for porcine leukocytes. The peptide was synthesized by the solid-phase method using ...

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ژورنال

عنوان ژورنال: Asian-Australasian Journal of Animal Sciences

سال: 2004

ISSN: 1011-2367,1976-5517

DOI: 10.5713/ajas.2004.1635